PROPER USE
What should I do before I inject TAKHZYRO?
Do not inject yourself or someone else until you have been trained by your healthcare professional.
Be sure that you read, understand, and follow the step-by-step instructions for injecting TAKHZYRO. A healthcare professional will show you how to prepare and inject TAKHZYRO properly before you use it for the first time. Contact your healthcare professional if you have any questions.
- You should always follow the specific instructions given by your healthcare professional. The steps listed below are general guidelines for using TAKHZYRO. If you are unsure of the steps, contact your healthcare professional before using TAKHZYRO.
Do not inject yourself or someone else until you have been trained by your healthcare professional.
Be sure that you read, understand, and follow the step-by-step instructions for injecting TAKHZYRO. A healthcare professional will show you how to prepare and inject TAKHZYRO properly before you use it for the first time. Contact your healthcare professional if you have any questions.
- You should always follow the specific instructions given by your healthcare professional. The steps listed below are general guidelines for using TAKHZYRO. If you are unsure of the steps, contact your healthcare professional before using TAKHZYRO.
Instructions for use – Vial
- Only use the syringes, blunt tip vial access needles, and pointed tip administration (injection) needles that your healthcare professional prescribes.
- Only use the syringes, blunt tip vial access needles and pointed tip administration (injection) needles one time. Discard (throw away) any used syringes and needles in the proper disposal container.
Preparation:
- Collect all supplies listed here to prepare and give your injection.
- Inspect the supplies for damage. Do not use if they appear damaged.
TAKHZYRO is a solution for injection under the skin (subcutaneous injection). It is supplied in a single-use, glass vial at a dosage of 300 mg/2 mL solution.
Gather the medication and other recommended supplies.
Gather an empty 3-mL syringe, 18 G blunt tip vial access needle, 27G ½-inch pointed tip administration (injection) needle. You will also need an alcohol swab, cotton ball/gauze pad, adhesive bandage, and sharps disposal container. These supplies are not included in the TAKHZYRO packaging.
Vial containing TAKHZYRO
Alcohol swabs
Cotton ball/gauze pad
Adhesive bandage
One (1) empty 3 mL syringe
One (1) 18G blunt tip vial access needle (longer needle). Used to draw drug from the vial into the syringe.
One (1) 27G ½-inch pointed tip administration (injection) needle (shorter needle). Used for injection under the skin (subcutaneous).
Sharps disposal container
These are the recommended supplies. However, your healthcare professional may choose what is most appropriate for you.
Instructions for use – Prefilled syringe
Preparation:
- Collect all supplies listed below to prepare and give your injection.
- Inspect the supplies for damage. Do not use if they appear damaged.
TAKHZYRO is a solution for injection under the skin (subcutaneous injection). It is supplied in a single-use prefilled syringe at a dosage of 300 mg/2 mL solution.
Parts of your TAKHZYRO prefilled syringe before use
Your guide to injection
Prepare the vial of TAKHZYRO
Attach the blunt tip
Transfer TAKHZYRO into syringe
Select and prepare injection site
Inject TAKHZYRO
Prepare the vial of TAKHZYRO
- Take the vial out of the refrigerator 15 minutes before use and allow it to reach room temperature before preparing an injection.
- Gather your TAKHZYRO and supplies and place them on your well-lit work surface.
- Check the expiration date on the box, on the vial label. Do not use if the expiration date has passed.
- Clean your work area and wash your hands prior to preparing your dose. Do not touch any surface or body part, especially your face, after washing your hands before injection.
- Remove the vial from the packaging.
Prepare the vial of TAKHZYRO
- Gently invert the vial 3 to 5 times to ensure the solution is mixed. Do not shake to avoid foaming.
- Look at the solution in the vial for visible particles or a change in the colour (normally colourless to slightly yellow). Do not use if you see particles or a change in colour.
Important : Do not shake the vial.
Prepare the vial of TAKHZYRO
- Remove the plastic cap from the drug vial. Do not remove the drug vial rubber stopper.
Prepare the vial of TAKHZYRO
- Place the vial on a flat surface. Clean the drug vial rubber stopper with an alcohol wipe and allow it to dry.
Attach the blunt tip vial access needle to syringe
- Screw the 18G blunt tip vial access needle to the 3 mL syringe.
Important : Do not remove the needle cap from the needle when attaching to the syringe.
Attach the blunt tip vial access needle to syringe
- Pull back the plunger to fill the syringe with air equal to the amount of drug in the vial.
Attach the blunt tip vial access needle to syringe
- Pull off the needle cap straight away from the syringe without touching the needle. Do not pull on the plunger.
Transfer TAKHZYRO into syringe and switch to the pointed tip administration (injection) needle
- Insert the needle into the centre of the rubber stopper.
- Push the plunger down to inject air into the vial and hold the plunger down.
Transfer TAKHZYRO into syringe and switch to the pointed tip administration (injection) needle
- Slowly turn the vial upside down with needle and syringe attached. Pull back on the plunger to withdraw the full dose in the vial.
Important : Be sure to keep the tip of the needle in the liquid to avoid drawing air in as you pull back the plunger.
Transfer TAKHZYRO into syringe and switch to the pointed tip administration (injection) needle
- Remove large air bubbles by gently tapping on the syringe with your fingers until the bubbles rise to the top of the syringe.
- Slowly push the plunger, allowing air to go back into the vial, until the drug reaches the top of the syringe.
- Repeat these steps until large bubbles are removed.
Transfer TAKHZYRO into syringe and switch to the pointed tip administration (injection) needle
- Without removing the needle from the vial, unscrew the syringe by holding the needle hub and turning the syringe counter clockwise. Be careful not to press down on the plunger, as the drug will be pushed out.
- Return the syringe to an upright position.
Transfer TAKHZYRO into syringe and switch to the pointed tip administration (injection) needle
- Discard the vial with the 18G needle still inside into a sharps container.
Transfer TAKHZYRO into syringe and switch to the pointed tip administration (injection) needle
- Screw the 27G ½-inch administration (injection) needle to the syringe.
Important : Do not remove the needle cap from the needle when attaching to the syringe.
Do not use the blunt tip vial access needle to inject TAKHZYRO as this may cause harm such as pain and bleeding.
Select and prepare injection site
- Choose a subcutaneous injection site on your stomach (abdomen), thigh, or upper arm.
Select and prepare injection site
Important :
- Rotate injection sites to keep skin healthy.
- The area you choose for injection should be at least 2 inches (5 cm) away from any scars or your belly button (navel). Do not choose an area that is bruised, swollen, or painful.
- The outer area of the upper arm is not recommended for self-administration.
Select and prepare injection site
Important :
- TAKHZYRO must be administered within 2 hours of preparing your dosing syringe at room temperature. After the dosing syringe is prepared, it can be refrigerated (2-8°C) and must be used within 8 hours of preparation. Take the prepared syringe out of the fridge 15 minutes before use to allow it to reach room temperature before injecting.
- Clean your injection site with an alcohol wipe and allow it to dry completely.
Inject TAKHZYRO
- Pull off the needle cap straight away from the syringe without touching the needle. Do not pull on the plunger. Do not touch the needle tip or allow it to touch any other surface.
Inject TAKHZYRO
- Gently pinch 1 inch/ 2.5 cm of skin at your cleaned injection site and insert the needle.
Important : Be sure to inject into a subcutaneous space which is not too shallow (skin layer) or too deep (muscle).
Inject TAKHZYRO
- Push the plunger slowly until no contents remain in the syringe. Release the skin fold and gently remove the needle. Do not recap the needle.
- Press the cotton ball or gauze pad over the injection site if needed and hold for 10 seconds.
- Do not rub the injection site. You may have a minor bleeding. This is normal.
- Cover the injection site with an adhesive bandage if needed.
Inject TAKHZYRO
- Place the 27G ½-inch administration (injection) needle and the syringe in a sharps container.
There may be provincial and local laws about the right way to throw away used vials, syringes, and needles. Ask your healthcare professional how to throw away used vials, syringes, and needles.
Your guide to injection
Prepare for your injection
Select and prepare injection site
Inject TAKHZYRO
Prepare for your injection
- Gather an alcohol swab, cotton ball/gauze pad, adhesive bandage, and sharps disposal container and place them on a clean, flat, surface in a well-lit area. These supplies are not included in the TAKHZYRO packaging.
Prepare for your injection
- Remove TAKHZYRO from the refrigerator, open the carton box and remove the TAKHZYRO prefilled syringe from the tray.
- Before you prepare your injection, allow the prefilled syringe to come to room temperature for at least 15 minutes.
- Your medicine is sensitive to warm temperatures. Do not use external heat sources such as hot water to warm your TAKHZYRO prefilled syringe.
- Do not remove the needle cap until you are ready to inject.
Prepare for your injection
- Wash your hands with soap and water. Dry your hands completely.
Prepare for your injection
- Check the expiration date on the label.
- Do not use the TAKHZYRO prefilled syringe if the expiration date has passed.
- Visually inspect the TAKHZYRO prefilled syringe for any damage and make sure the medicine is colourless to slightly yellow.
- Do not use the product if the syringe is damaged (e.g., cracked syringe).
- Do not administer if the medicine is discoloured, cloudy or has flakes or particles in it.
- You might see air bubbles in the TAKHZYRO prefilled syringe. This is normal and will not affect your dose.
Select and prepare the injection site
- TAKHZYRO should be injected into your stomach (abdomen) or thigh. If given by a caregiver, TAKHZYRO may also be injected in the upper arm.
- It is important to rotate injection sites to keep skin healthy. Each new injection should be given at least 2 inches (5 cm) from the last site you used.
- Do not inject into an area of your body where the skin is irritated, reddened, bruised, or infected.
- The area you choose for injection should be at least 2 inches (5 cm) away from any scars or your belly button (navel).
Select and prepare the injection site
- Clean the injection site with an alcohol swab and allow it to dry.
- Do not fan or blow on the clean site.
- Do not touch this area again before giving your injection.
Select and prepare the injection site
- Remove the needle cap from the TAKHZYRO prefilled syringe. Gently pull the needle cap straight off with one hand and firmly hold the middle of the TAKHZYRO prefilled syringe with the other hand. Throw away the needle cap.
- Do not recap your TAKHZYRO prefilled syringe.
- Do not use the TAKHZYRO prefilled syringe if it has been dropped without the needle cap on or if the needle looks damaged or bent.
- Do not touch the needle or allow the needle to touch anything.
Inject TAKHZYRO
- Grip the TAKHZYRO prefilled syringe in one hand like a pencil. Avoid touching the needle or pushing on the plunger.
- With your other hand, gently pinch a 1-inch (2.5 cm) fold of skin at the cleaned injection site.
Inject TAKHZYRO
- Using a quick dart-like motion, insert the needle. Make sure to keep the needle in place.
- Slowly push the plunger until all of the liquid is injected and the syringe is empty, then gently let go of your skin.
Inject TAKHZYRO
- Slowly withdraw the needle while maintaining the syringe at the same angle.
- Press the cotton ball or gauze pad over the injection site if needed, and hold for 10 seconds.
- Do not rub the injection site. You may have a minor bleeding. This is normal.
- Cover the injection site with an adhesive bandage if needed.
Inject TAKHZYRO
- Throw away (dispose of) your used TAKHZYRO prefilled syringe.
- Do not touch the needle.
- To avoid a needle-stick injury, do not recap the needle.
- Put your used TAKHZYRO prefilled syringes in a sharps disposal container right away after use. Do not reuse the TAKHZYRO prefilled syringe and any of your injection supplies.
There may be provincial and local laws about the right way to throw away used syringes. Ask your healthcare professional how to throw away used syringes.
Please click here to download a PDF of these instructions.