About HAE

What is hereditary angioedema (HAE)?

HAE is a rare genetic disorder that occurs in about 1 in 10,000 to 1 in 50,000 people worldwide.

The clinical course of HAE attacks is unpredictable.

HAE is characterized by episodes of swelling (edema attacks) in different areas of the skin or the internal organs.

Edema of the skin occurs mainly in the face (e.g., lips, eyelids), although the extremities and genitals are also often affected
Edema of the mucous membranes affects the larynx, nose, or tongue
Abdominal pain is reported by 70-80% of patients with HAE

In HAE, uncontrolled production of a substance called plasma kallikrein occurs. This leads to the release of too much bradykinin in your bloodstream. Too much bradykinin leads to symptoms like swelling and pain (HAE attack).

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